US8268614B2 - Method for assaying cell movement - Google Patents
Method for assaying cell movement Download PDFInfo
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- US8268614B2 US8268614B2 US10/579,118 US57911804A US8268614B2 US 8268614 B2 US8268614 B2 US 8268614B2 US 57911804 A US57911804 A US 57911804A US 8268614 B2 US8268614 B2 US 8268614B2
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- 239000003071 vasodilator agent Substances 0.000 description 1
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- 229960001722 verapamil Drugs 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
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- RUDFQVOCFDJEEF-UHFFFAOYSA-N yttrium(III) oxide Inorganic materials [O-2].[O-2].[O-2].[Y+3].[Y+3] RUDFQVOCFDJEEF-UHFFFAOYSA-N 0.000 description 1
- 150000003952 β-lactams Chemical class 0.000 description 1
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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Abstract
Description
(RO)3—Si—R1—X1 (1)
where R is an alkyl group, such as methyl or ethyl, R1 is a linking group between silicon and X and X is a reactive group or a protected reactive group. The reactive group can also be a recognition moiety as discussed below. Silane derivatives having halogens or other leaving groups beside the displayed alkoxy groups are also useful in the present invention.
-
- 1. Hydroxyalkyl siloxanes (Silylate surface, functionalize with diborane, and H2O2 to oxidize the alcohol)
- a. allyl trichlorosilane→→3-hydroxypropyl
- b. 7-oct-1-enyl trichlorosilane→→8-hydroxyoctyl
- 2. Diol(dihydroxyalkyl)siloxanes (silylate surface and hydrolyze to diol)
- a. (glycidyl triethoxysilane→→(2,3-dihydroxypropyloxy)propyl
- 3. Aminoalkyl siloxanes (amines requiring no intermediate functionalizing step).
- a. 3-aminopropyl trimethoxysilane→aminopropyl
- 4. Dimeric secondary aminoalkyl siloxanes
- a. bis(3-trimethoxysilylpropyl)amine→bis(silyloxylpropyl)amine.
- 1. Hydroxyalkyl siloxanes (Silylate surface, functionalize with diborane, and H2O2 to oxidize the alcohol)
Y—S—R2—X2 (2)
(RO)3—Si—R2—(X2)n (3)
where R is an alkyl group, such as methyl, R2 is a linking group between silicon and X2, X2 is a reactive group or a protected reactive group and n is an integer between 2 and 50, and more preferably between 2 and 20.
Y—S—R2—(X2)n (4)
As discussed above, R2 is a linking group between sulfur and X2 and X2 is a reactive group or a protected reactive group. X2 can also be a recognition moiety. Y is a member selected from the group consisting of H, R3 and R3—S—, wherein R2 and R3 are independently selected.
X1Q2C(CQ1 2)mZ1(CQ2 2)nSH (5)
wherein, X1 is a member selected from the group consisting of H, halogen reactive groups and protected reactive groups. Reactive groups can also be recognition moieties as discussed below. Q, Q1 and Q2 are independently members selected from the group consisting of H and halogen. Z1 is a member selected from the group consisting of —CQ2—, —CQ1 2—, —CQ2 2—, —O—, —S—, NR4—, —C(O) NR4 and R4NC(O0-, in which R4 is a member selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl and heterocyclic groups and m and n are independently a number between 0 and 40.
CF3(CF2)mZ1(CH2)nSH (6)
CF3(CF2)oZ2(CH2)pSH (7)
wherein, Z1 and Z2 are members independently selected from the group consisting of —CH2—, —O—, —S—, NR4, —C(O)NR4 and R4NC(O)— in which R4 is a member selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl and heterocyclic groups. In a presently preferred embodiment, the Z groups of adjacent molecules participate in either an attractive (e.g., hydrogen bonding) or repulsive (e.g., van der Waals) interaction.
TABLE 1 |
Molecular structure of mesogens suitable for use in Liquid |
Crystal Assay Devices |
Mesogen | Structure |
Anisaldazine |
|
NCB |
|
CBOOA |
|
Comp A |
|
Comp B |
|
DB7NO2 |
|
DOBAMBC |
|
nOm n = 1, m = 4: MBBA n = 2, m = 4: EBBA |
|
nOBA n = 8: OOBA n = 9: NOBA |
|
nmOBC |
|
nOCB |
|
nOSI |
|
98P |
|
PAA |
|
PYP906 |
|
|
|
TABLE 2 |
Survey of liquid crystals for alignment |
by cells and by slide exposed to medium. |
Liquid Crystal | FBS/DMEM | 3T3 cells |
4OCB | Disrupted | Homeotropic |
5CB | Disrupted | Homeotropic |
6CHBT | Planar, with defects | Homeotropic |
E7 | Disrupted | Homeotropic |
ZLI-1221 | Planar, streaky | Disrupted |
ZLI-1557 | Planar with streaky defects | Homeotropic |
ZLI-2222 | Planar, minor defects | Homeotropic |
ZLI-3225 | Planar with streaky defects | Homeotropic (tilt) |
ZLI-3497 | Planar with streaky defects | Homeotropic (tilt) |
ZLI-4431 | Planar with streaky defects | Homeotropic (tilt) |
ZLI-4446 | Planar, with defects | Homeotropic |
ZLI-5070 | Planar with streaky defects | Homeotropic (tilt) |
MLC-6080 | Planar with squiggly defects | Homeotropic |
MLC-6466 | Planar with streaky defects | Homeotropic |
MLC-6710-080 | Planar with streaky defects | Homeotropic |
MLC-15700-000 | Planar, streaky | Homeotropic |
TL205 | Somewhat planar | Homeotropic |
TABLE 3 |
Investigation of phospholipid influence on liquid crystal alignment. |
Liquid Crystal | Bkg | DOPS | DOPG | DOPC | DOPE | DOPA | DOLPC | Chol |
4OCB | H | ND | ND | ND | ND | ND | ND | ND |
5CB | U | H | H | H | Planar | H | U | |
6CHBT | U | H | H | H | H | H | U | |
E7 | Twisted | H | H | H | Twisted | H | H | |
planar | planar | |||||||
ZLI-1221 | H | H | H | H | H | H | H | |
ZLI-1557 | H | H | H | H | H | H | H | |
ZLI-2222 | H | H | H | H | H | H | H | |
ZLI-3225 | U | H | H | H | H | H | H | |
ZLI-3497 | H | ND | ND | ND | ND | ND | ND | ND |
ZLI-4431 | Chol | U | U | U | U | U | U | U |
ZLI-4446 | H | ND | ND | ND | ND | ND | ND | ND |
ZLI-5070 | Twisted | H | H | H | H | H | H | |
planar | ||||||||
MLC-6080 | U | H | H | H | H | H | H | |
MLC-6466 | U | H | H | H | H | H | H | |
MLC-6710-080 | U | H | H | H | H | H | H | |
MLC-15700-000 | H | H | H | U | H | H | U | |
TL205 | U | H | H | H | H | H | H | |
Claims (8)
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US10/443,419 US7018838B2 (en) | 2002-05-22 | 2003-05-22 | Substrates, devices, and methods for cellular assays |
US51870603P | 2003-11-10 | 2003-11-10 | |
US10/579,118 US8268614B2 (en) | 2002-05-22 | 2004-11-10 | Method for assaying cell movement |
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WO2005047863A3 (en) | 2006-02-09 |
EP1687396A2 (en) | 2006-08-09 |
AU2004290432A1 (en) | 2005-05-26 |
US20130040332A1 (en) | 2013-02-14 |
AU2009200682A1 (en) | 2009-03-12 |
US20130344582A1 (en) | 2013-12-26 |
AU2004290432B2 (en) | 2008-11-20 |
US8512974B2 (en) | 2013-08-20 |
CA2545482A1 (en) | 2005-05-26 |
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US20070178534A1 (en) | 2007-08-02 |
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