WO2002055186A3 - Surface modified semiconductive and metallic nanoparticlse having enhanced dispersibility in aqueous media - Google Patents

Surface modified semiconductive and metallic nanoparticlse having enhanced dispersibility in aqueous media Download PDF

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Publication number
WO2002055186A3
WO2002055186A3 PCT/US2001/042699 US0142699W WO02055186A3 WO 2002055186 A3 WO2002055186 A3 WO 2002055186A3 US 0142699 W US0142699 W US 0142699W WO 02055186 A3 WO02055186 A3 WO 02055186A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrophobic
hydrophilic
metallic
nanoparticlse
aqueous media
Prior art date
Application number
PCT/US2001/042699
Other languages
French (fr)
Other versions
WO2002055186A2 (en
Inventor
Edward William Adams
Marcel Pierre Bruchez, Jr.
Original Assignee
Quantum Dot Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantum Dot Corporation filed Critical Quantum Dot Corporation
Priority to AU2002243207A priority Critical patent/AU2002243207A1/en
Priority to JP2002555911A priority patent/JP4638128B2/en
Priority to EP01989086.2A priority patent/EP1326704B1/en
Priority to CA 2424082 priority patent/CA2424082C/en
Publication of WO2002055186A2 publication Critical patent/WO2002055186A2/en
Publication of WO2002055186A3 publication Critical patent/WO2002055186A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/88—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing selenium, tellurium or unspecified chalcogen elements
    • C09K11/881—Chalcogenides
    • C09K11/883—Chalcogenides with zinc or cadmium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31855—Of addition polymer from unsaturated monomers
    • Y10T428/31909—Next to second addition polymer from unsaturated monomers
    • Y10T428/31928—Ester, halide or nitrile of addition polymer

Abstract

Water-dispersible nanoparticles are prepared by applying a coating of a multiply amphipathic dispersant to the surface of a hydrophobic nanoparticle comprised of a semiconductive or metallic material. The multiply amphipathic dispersant has two or more hydrophobic regions and two or more hydrophilic regions, and is typically polymeric. Preferred polymeric dispersants are comprised of (1) a hydrophobic backbone with hacdrophilic branches, (2) a hydrophilic backbone with hydrophobic branches, or (3) a backbone that may be either hydrophobic or hydrophilic, and substituted with both hydrophilic and hydrophobic branches. Monodisperse populations of water-dispersible nanoparticles are also provided, as are conjugates of the water-dispersible nanoparticles with afinity molecules such as peptides, oligonucleotides, and the like.
PCT/US2001/042699 2000-10-13 2001-10-12 Surface modified semiconductive and metallic nanoparticlse having enhanced dispersibility in aqueous media WO2002055186A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002243207A AU2002243207A1 (en) 2000-10-13 2001-10-12 Surface modified semiconductive and metallic nanoparticlse having enhanced dispersibility in aqueous media
JP2002555911A JP4638128B2 (en) 2000-10-13 2001-10-12 Surface-modified semiconducting and metallic nanoparticles with enhanced dispersibility in aqueous media
EP01989086.2A EP1326704B1 (en) 2000-10-13 2001-10-12 Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
CA 2424082 CA2424082C (en) 2000-10-13 2001-10-12 Surface modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24021600P 2000-10-13 2000-10-13
US60/240,216 2000-10-13
US09/841,237 US6649138B2 (en) 2000-10-13 2001-04-23 Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
US09/841,237 2001-04-23

Publications (2)

Publication Number Publication Date
WO2002055186A2 WO2002055186A2 (en) 2002-07-18
WO2002055186A3 true WO2002055186A3 (en) 2003-03-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/042699 WO2002055186A2 (en) 2000-10-13 2001-10-12 Surface modified semiconductive and metallic nanoparticlse having enhanced dispersibility in aqueous media

Country Status (6)

Country Link
US (7) US6649138B2 (en)
EP (2) EP2233202A3 (en)
JP (2) JP4638128B2 (en)
AU (1) AU2002243207A1 (en)
CA (1) CA2424082C (en)
WO (1) WO2002055186A2 (en)

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