WO2002056021A3 - Polymer brushes for immobilizing molecules to a surface - Google Patents

Polymer brushes for immobilizing molecules to a surface Download PDF

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Publication number
WO2002056021A3
WO2002056021A3 PCT/US2002/000746 US0200746W WO02056021A3 WO 2002056021 A3 WO2002056021 A3 WO 2002056021A3 US 0200746 W US0200746 W US 0200746W WO 02056021 A3 WO02056021 A3 WO 02056021A3
Authority
WO
WIPO (PCT)
Prior art keywords
functional groups
substrate
allows
water
sensors
Prior art date
Application number
PCT/US2002/000746
Other languages
French (fr)
Other versions
WO2002056021A2 (en
Inventor
Gerrit Klaerner
Didier Benoit
Dominique Charmot
Srinivas Nomula
Marcelo E. Piotti
Laura T. Mazzola
Original Assignee
Symyx Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symyx Technologies, Inc. filed Critical Symyx Technologies, Inc.
Priority to AU2002246978A priority Critical patent/AU2002246978A1/en
Publication of WO2002056021A2 publication Critical patent/WO2002056021A2/en
Publication of WO2002056021A3 publication Critical patent/WO2002056021A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent

Abstract

Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.
PCT/US2002/000746 2001-01-10 2002-01-10 Polymer brushes for immobilizing molecules to a surface WO2002056021A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002246978A AU2002246978A1 (en) 2001-01-10 2002-01-10 Polymer brushes for immobilizing molecules to a surface

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27169201P 2001-01-10 2001-01-10
US60/271,692 2001-01-10

Publications (2)

Publication Number Publication Date
WO2002056021A2 WO2002056021A2 (en) 2002-07-18
WO2002056021A3 true WO2002056021A3 (en) 2003-09-18

Family

ID=23036653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/000746 WO2002056021A2 (en) 2001-01-10 2002-01-10 Polymer brushes for immobilizing molecules to a surface

Country Status (3)

Country Link
US (1) US7205161B2 (en)
AU (1) AU2002246978A1 (en)
WO (1) WO2002056021A2 (en)

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US20030108879A1 (en) 2003-06-12
US7205161B2 (en) 2007-04-17
WO2002056021A2 (en) 2002-07-18
AU2002246978A1 (en) 2002-07-24

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