WO2005040343A3 - Improved apparatus and method for identification of biomolecules, in particular nucleic acid sequences, proteins, and antigens and antibodies - Google Patents

Improved apparatus and method for identification of biomolecules, in particular nucleic acid sequences, proteins, and antigens and antibodies Download PDF

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Publication number
WO2005040343A3
WO2005040343A3 PCT/US2004/030040 US2004030040W WO2005040343A3 WO 2005040343 A3 WO2005040343 A3 WO 2005040343A3 US 2004030040 W US2004030040 W US 2004030040W WO 2005040343 A3 WO2005040343 A3 WO 2005040343A3
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WO
WIPO (PCT)
Prior art keywords
antigens
antibodies
proteins
biomolecules
identification
Prior art date
Application number
PCT/US2004/030040
Other languages
French (fr)
Other versions
WO2005040343A2 (en
Inventor
Randall W Davis
Original Assignee
Randall W Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Randall W Davis filed Critical Randall W Davis
Priority to JP2006533918A priority Critical patent/JP2007508543A/en
Priority to EP04788748A priority patent/EP1687397A2/en
Publication of WO2005040343A2 publication Critical patent/WO2005040343A2/en
Publication of WO2005040343A3 publication Critical patent/WO2005040343A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors

Abstract

An electrical detection system and method using an array of conductive sense sites within a sensing substrate for electrically detecting the successful hybridization or binding reaction between two chemical substances, particularly between blogenic substances such as nucleotides, proteins and ligands, and antigens and antibodies. The method and apparatus provide a an inexpensive, robust, small, repeatable, and intuitively easy to use apparatus for detection of low levels of hybridization with large numbers of closely spaced conductive sense sites within a single substrate.
PCT/US2004/030040 2003-10-08 2004-09-14 Improved apparatus and method for identification of biomolecules, in particular nucleic acid sequences, proteins, and antigens and antibodies WO2005040343A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2006533918A JP2007508543A (en) 2003-10-08 2004-09-14 Improved method and apparatus for identification of biological molecules and methods for identification of nucleic acid sequences, proteins, antigens and antibodies
EP04788748A EP1687397A2 (en) 2003-10-08 2004-09-14 Improved apparatus and method for identification of biomolecules, in particular nucleic acid sequences, proteins, and antigens and antibodies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/681,630 2003-10-08
US10/681,630 US20050079598A1 (en) 2003-10-08 2003-10-08 Apparatus and method for identification of biomolecules, in particular nucleic acid sequences, proteins, and antigens and antibodies

Publications (2)

Publication Number Publication Date
WO2005040343A2 WO2005040343A2 (en) 2005-05-06
WO2005040343A3 true WO2005040343A3 (en) 2006-11-30

Family

ID=34422323

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/030040 WO2005040343A2 (en) 2003-10-08 2004-09-14 Improved apparatus and method for identification of biomolecules, in particular nucleic acid sequences, proteins, and antigens and antibodies

Country Status (4)

Country Link
US (1) US20050079598A1 (en)
EP (1) EP1687397A2 (en)
JP (1) JP2007508543A (en)
WO (1) WO2005040343A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4696723B2 (en) * 2005-06-28 2011-06-08 ソニー株式会社 Biosensor
TW200837349A (en) * 2007-03-07 2008-09-16 Nat Univ Tsing Hua Biochip and manufacturing method thereof
US8198658B2 (en) * 2007-06-13 2012-06-12 Samsung Electronics Co., Ltd. Device and method for detecting biomolecules using adsorptive medium and field effect transistor
EP2250491A4 (en) * 2008-03-07 2013-06-26 California Inst Of Techn Effective-inductance-change based magnetic particle sensing
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
US9068022B1 (en) 2008-05-06 2015-06-30 General Mills, Inc. Process for making a modified starch product
US20100088816A1 (en) * 2008-10-10 2010-04-15 Brian David Rollins Washer Apparatus
US9599591B2 (en) 2009-03-06 2017-03-21 California Institute Of Technology Low cost, portable sensor for molecular assays
JP2011232328A (en) * 2010-04-09 2011-11-17 Hitachi Ltd Biological substance detection array, measurement device and measurement method
US9567630B2 (en) 2013-10-23 2017-02-14 Genia Technologies, Inc. Methods for forming lipid bilayers on biochips
US10036739B2 (en) 2015-01-27 2018-07-31 Genia Technologies, Inc. Adjustable bilayer capacitance structure for biomedical devices
CN105067817B (en) * 2015-07-08 2017-05-10 上海清流生物医药科技有限公司 Methods and devices for acquiring signals and tracking cells by adopting light sensitive chips
US10809243B2 (en) 2015-08-31 2020-10-20 Roche Sequencing Solutions, Inc. Small aperture large electrode cell
US10656079B2 (en) 2016-02-01 2020-05-19 Micro Detect, Inc. UV solid state detection and methods therefor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999057550A1 (en) * 1998-05-04 1999-11-11 Technion Research And Development Foundation Ltd. Detection of a target in a sample
US6176990B1 (en) * 1995-06-08 2001-01-23 Visible Genetics Inc. Micro-electrophoresis chip for moving and separating nucleic acids and other charged molecules
US6236088B1 (en) * 1997-06-30 2001-05-22 Intersil Corporation Semiconductor device gate structure for thermal overload protection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6176990B1 (en) * 1995-06-08 2001-01-23 Visible Genetics Inc. Micro-electrophoresis chip for moving and separating nucleic acids and other charged molecules
US6236088B1 (en) * 1997-06-30 2001-05-22 Intersil Corporation Semiconductor device gate structure for thermal overload protection
WO1999057550A1 (en) * 1998-05-04 1999-11-11 Technion Research And Development Foundation Ltd. Detection of a target in a sample

Also Published As

Publication number Publication date
US20050079598A1 (en) 2005-04-14
JP2007508543A (en) 2007-04-05
EP1687397A2 (en) 2006-08-09
WO2005040343A2 (en) 2005-05-06

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