WO2006080937A3 - Screening assays for antimicrobial agents - Google Patents
Screening assays for antimicrobial agents Download PDFInfo
- Publication number
- WO2006080937A3 WO2006080937A3 PCT/US2005/014398 US2005014398W WO2006080937A3 WO 2006080937 A3 WO2006080937 A3 WO 2006080937A3 US 2005014398 W US2005014398 W US 2005014398W WO 2006080937 A3 WO2006080937 A3 WO 2006080937A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptides
- antimicrobial agents
- screening assays
- screening
- biological activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
Abstract
The present invention provides methods for screening antimicrobial agents that make use of mutated microbial polypeptides. Because these polypeptides have biological activity and result in increased antimicrobial drug resistance, candidate compounds that specifically target these polypeptides provide therapeutics or therapeutic lead compounds for treating infections caused by drug resistant microbial pathogens.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56567904P | 2004-04-27 | 2004-04-27 | |
US60/565,679 | 2004-04-27 | ||
US56685804P | 2004-04-30 | 2004-04-30 | |
US60/566,858 | 2004-04-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006080937A2 WO2006080937A2 (en) | 2006-08-03 |
WO2006080937A3 true WO2006080937A3 (en) | 2009-04-16 |
Family
ID=36740916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/014398 WO2006080937A2 (en) | 2004-04-27 | 2005-04-27 | Screening assays for antimicrobial agents |
Country Status (2)
Country | Link |
---|---|
US (1) | US20050282242A1 (en) |
WO (1) | WO2006080937A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7713689B2 (en) * | 2005-09-15 | 2010-05-11 | Duke University | Non-fouling polymeric surface modification and signal amplification method for biomolecular detection |
US8796184B2 (en) | 2008-03-28 | 2014-08-05 | Sentilus, Inc. | Detection assay devices and methods of making and using the same |
US20130149701A1 (en) * | 2010-06-17 | 2013-06-13 | Ying Zhang | Methods of identifying therapeutic agents for treating persister and bacterial infection |
WO2015061322A1 (en) * | 2013-10-23 | 2015-04-30 | University Of Virginia Patent Foundation | Compositions and methods for using and identifying antimicrobial agents |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6153381A (en) * | 1997-08-28 | 2000-11-28 | Millennium Pharmaceuticals, Inc. | Screening for antibiotics |
US6783930B1 (en) * | 1998-12-03 | 2004-08-31 | Jerry Pelletier | Development of novel anti-microbial agents based on bacteriophage genomics |
-
2005
- 2005-04-27 WO PCT/US2005/014398 patent/WO2006080937A2/en active Application Filing
- 2005-04-27 US US11/115,639 patent/US20050282242A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6153381A (en) * | 1997-08-28 | 2000-11-28 | Millennium Pharmaceuticals, Inc. | Screening for antibiotics |
US6783930B1 (en) * | 1998-12-03 | 2004-08-31 | Jerry Pelletier | Development of novel anti-microbial agents based on bacteriophage genomics |
Non-Patent Citations (1)
Title |
---|
WIEBOLDT ET AL., ANAL. CHEM., vol. 69, pages 1683 - 1691 * |
Also Published As
Publication number | Publication date |
---|---|
WO2006080937A2 (en) | 2006-08-03 |
US20050282242A1 (en) | 2005-12-22 |
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121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
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122 | Ep: pct application non-entry in european phase |