WO2013003624A3 - The capture, purification and release of biological substance using a surface coating - Google Patents

The capture, purification and release of biological substance using a surface coating Download PDF

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Publication number
WO2013003624A3
WO2013003624A3 PCT/US2012/044701 US2012044701W WO2013003624A3 WO 2013003624 A3 WO2013003624 A3 WO 2013003624A3 US 2012044701 W US2012044701 W US 2012044701W WO 2013003624 A3 WO2013003624 A3 WO 2013003624A3
Authority
WO
WIPO (PCT)
Prior art keywords
biological substance
composition
capture
surface coating
purification
Prior art date
Application number
PCT/US2012/044701
Other languages
French (fr)
Other versions
WO2013003624A2 (en
Inventor
Ying-Chih Chang
Han-Chung Wu
Po-Yuan TSENG
Original Assignee
Academia Sinica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academia Sinica filed Critical Academia Sinica
Priority to EP12805303.0A priority Critical patent/EP2726870B1/en
Priority to CN201280041521.0A priority patent/CN103998932B/en
Priority to US14/128,354 priority patent/US9541480B2/en
Publication of WO2013003624A2 publication Critical patent/WO2013003624A2/en
Publication of WO2013003624A3 publication Critical patent/WO2013003624A3/en
Priority to US15/378,938 priority patent/US20170199184A1/en
Priority to US16/832,396 priority patent/US11674958B2/en
Priority to US18/308,531 priority patent/US20230366879A1/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K17/00Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14Peptides being immobilised on, or in, an inorganic carrier
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • G01N1/405Concentrating samples by adsorption or absorption
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54386Analytical elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells

Abstract

This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.
PCT/US2012/044701 2011-06-29 2012-06-28 The capture, purification and release of biological substance using a surface coating WO2013003624A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP12805303.0A EP2726870B1 (en) 2011-06-29 2012-06-28 The capture, purification and release of biological substance using a surface coating
CN201280041521.0A CN103998932B (en) 2011-06-29 2012-06-28 Capture, purifying and release using face coat to biological substance
US14/128,354 US9541480B2 (en) 2011-06-29 2012-06-28 Capture, purification, and release of biological substances using a surface coating
US15/378,938 US20170199184A1 (en) 2011-06-29 2016-12-14 Capture, purification, and release of biological substances using a surface coating
US16/832,396 US11674958B2 (en) 2011-06-29 2020-03-27 Capture, purification, and release of biological substances using a surface coating
US18/308,531 US20230366879A1 (en) 2011-06-29 2023-04-27 Capture, purification, and release of biological substances using a surface coating

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161502844P 2011-06-29 2011-06-29
US61/502,844 2011-06-29
US201261606220P 2012-03-02 2012-03-02
US61/606,220 2012-03-02

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/128,354 A-371-Of-International US9541480B2 (en) 2011-06-29 2012-06-28 Capture, purification, and release of biological substances using a surface coating
US15/378,938 Continuation US20170199184A1 (en) 2011-06-29 2016-12-14 Capture, purification, and release of biological substances using a surface coating

Publications (2)

Publication Number Publication Date
WO2013003624A2 WO2013003624A2 (en) 2013-01-03
WO2013003624A3 true WO2013003624A3 (en) 2013-03-14

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Family Applications (1)

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PCT/US2012/044701 WO2013003624A2 (en) 2011-06-29 2012-06-28 The capture, purification and release of biological substance using a surface coating

Country Status (5)

Country Link
US (4) US9541480B2 (en)
EP (1) EP2726870B1 (en)
CN (3) CN110763842A (en)
TW (2) TWI550273B (en)
WO (1) WO2013003624A2 (en)

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